EECP® Therapy Mechanisms of Action
There is evidence demonstrating improved endothelial function via the hemodynamic effects by the increased shear stress acting on the arterial wall, reducing arterial stiffness and providing protective effects against inflammation, inhibiting intimal hyperplasia and the atherosclerotic process.
There is also evidence that EECP®/ECP Therapy triggers a neurohormonal response that induces the production of growth and vasodilatation factors, which together with the increased pressure gradient created across the occlusive site during EECP®/ECP Therapy, promotes recruitment of new arteries, while dilating and normalizing the function of existing blood vessels.
The collaterals bypass stenoses and increase blood flow to ischemic areas of the heart, leading to improved clinical outcomes
Vasomedical’s EECP® therapy begins with the inflation of the calf cuff followed sequentially by the thigh and buttock cuffs. Each cuff reaches its optimal pressure, of approximately 200mHg, in 50-70 ms. All three cuffs stay inflated at the optimal pressure throughout the cardiac cycle, with less than 20 mmHg pressure gradient between cuffs, until just before the next R wave when they simultaneously and rapidly deflate (50-80ms). This sequence of pressure is designed to permit maximal reduction of after-load and venous filing.
Vasomedical cuff system, provided in 5 sizes, is designed to ensure the uniformity of deliver of the pressures as described above. They are physiologically designed to provide patient comfort, which adds to patience compliance and effective therapy, while staying in proper position (high placement of the thigh cuff to effectively compress the femoral arterial bed) throughout the hour of treatment and ensuring the delivery of optimum therapy.